LUCIDus: LUCID with Multiple Omics Data

Implements Latent Unknown Clusters By Integrating Multi-omics Data (LUCID; Peng (2019) <doi:10.1093/bioinformatics/btz667>) for integrative clustering with exposures, multi-omics data, and health outcomes. Supports three integration strategies: early, parallel, and serial. Provides model fitting and tuning, lasso-type regularization for exposure and omics feature selection, handling of missing data, including both sporadic and complete-case patterns, prediction, and g-computation for estimating causal effects of exposures, bootstrap inference for uncertainty estimation, and S3 summary and plot methods. For the multi-omics integration framework, see Jia (2024) <https://journal.r-project.org/articles/RJ-2024-012/RJ-2024-012.pdf>. For the missing-data imputation mechanism, see Jia (2024) <doi:10.1093/bioadv/vbae123>.

Version: 3.1.0
Depends: R (≥ 3.6.0)
Imports: mclust, nnet, boot, jsonlite, networkD3, progress, stats, utils, glasso, glmnet
Suggests: testthat (≥ 3.0.0)
Published: 2026-03-11
DOI: 10.32614/CRAN.package.LUCIDus
Author: Qiran Jia ORCID iD [aut, cre], Yinqi Zhao ORCID iD [aut], David Conti ORCID iD [ths], Jesse Goodrich ORCID iD [ctb]
Maintainer: Qiran Jia <qiranjia at usc.edu>
License: MIT + file LICENSE
URL: https://journal.r-project.org/articles/RJ-2024-012/RJ-2024-012.pdf, https://doi.org/10.1093/bioadv/vbae123
NeedsCompilation: no
In views: MissingData, Omics
CRAN checks: LUCIDus results

Documentation:

Reference manual: LUCIDus.html , LUCIDus.pdf

Downloads:

Package source: LUCIDus_3.1.0.tar.gz
Windows binaries: r-devel: LUCIDus_3.0.3.zip, r-release: LUCIDus_3.0.3.zip, r-oldrel: LUCIDus_3.0.3.zip
macOS binaries: r-release (arm64): LUCIDus_3.0.3.tgz, r-oldrel (arm64): LUCIDus_3.0.3.tgz, r-release (x86_64): LUCIDus_3.0.3.tgz, r-oldrel (x86_64): LUCIDus_3.0.3.tgz
Old sources: LUCIDus archive

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