Simulates time-to-event (survival) datasets for clinical trial design and analysis, including datasets driven by a joint pharmacokinetic/pharmacodynamic (PK/PD) model solved via the 'mrgsolve' backend. Event times can be located directly during ODE integration ('in-solver' event detection) using a library of built-in PK/PD hazard models or a user-supplied 'mrgsolve' model converted for this purpose, or generated by inverse transform sampling from a closed-form Weibull or flexible M-spline baseline hazard, or from any externally simulated survival trajectory. See Bender et al. (2005) <doi:10.1002/sim.2059> for the inverse transform sampling methodology and Royston and Parmar (2002) <doi:10.1002/sim.1203> for flexible parametric survival models.
| Version: | 2.0.0 |
| Depends: | R (≥ 4.0.0) |
| Imports: | dplyr, magrittr, methods, mrgsolve, tools |
| Suggests: | callr, testthat (≥ 3.0.0), knitr, pkgload, rmarkdown, splines2, survival |
| Published: | 2026-11-07 |
| DOI: | 10.32614/CRAN.package.simtte |
| Author: | Carlos Traynor [aut, cre] |
| Maintainer: | Carlos Traynor <carlos.traynor.qcp at gmail.com> |
| BugReports: | https://github.com/csetraynor/simtte/issues |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: | https://github.com/csetraynor/simtte |
| NeedsCompilation: | no |
| Language: | en-US |
| Materials: | NEWS |
| CRAN checks: | simtte results |
| Reference manual: | simtte.html , simtte.pdf |
| Vignettes: |
Advanced Simulation Scenarios (source, R code) Bring Your Own PK/PD Model (source, R code) Censoring and Realistic Assessment Schedules (source, R code) Getting Started with simtte (source, R code) Joint PK/PD and Time-to-Event Simulation (source, R code) |
| Package source: | simtte_2.0.0.tar.gz |
| Windows binaries: | r-devel: simtte_1.0.2.zip, r-release: simtte_1.0.2.zip, r-oldrel: simtte_1.0.2.zip |
| macOS binaries: | r-release (arm64): simtte_1.0.2.tgz, r-oldrel (arm64): simtte_1.0.2.tgz, r-release (x86_64): simtte_1.0.2.tgz, r-oldrel (x86_64): simtte_1.0.2.tgz |
| Old sources: | simtte archive |
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